2 hours, every 28 days

Depending on your medical history, this may be your first experience with an infusion. Please know that trained healthcare professionals administer TYSABRI® (natalizumab) every 28 days at a TOUCH®-registered infusion center, doctor's office, or hospital.

Before the infusion, the doctor or nurse will discuss the risks and benefits of TYSABRI to determine if it is right for you.

What happens during an infusion?

During an infusion, fluid flows from a sterile bag through plastic tubing and a small needle into a vein in your arm. The infusion takes about an hour. You will be asked to wait for another hour to make sure you are not having a reaction that may need medical attention.

What do I do during the infusion?

We encourage people to treat the infusion experience as "me time." Since you have 2 hours to yourself, you might like to:

  • Read a book/magazine
  • Take a nap
  • Work on your laptop
  • Watch a movie
  • Listen to music

The infusion center is also a great place to share experiences with other people with relapsing multiple sclerosis (MS). Who knows, you may even make a few new friends.

Is there anything I would need to tell my doctor/nurse before each infusion?

It is important for you to share all of your medical conditions with your doctors and nurses. For example, if you:

  • Have any new or worsening problems that have lasted several days
  • Have had hives, itching, or trouble breathing during or after an infusion
  • Have had a fever or infection
  • Are taking any other medications, including prescription and non-prescription medicines, vitamins, and herbal supplements

You should let your doctor know if you are or plan to become pregnant. It is unknown if TYSABRI can harm your unborn baby. TYSABRI can pass into your breast milk. It is not known if the TYSABRI that passes into breast milk can harm your baby.

The Medication Guide can help you find more information regarding your infusion.


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TYSABRI® (natalizumab) is a prescription medicine used to treat adults with relapsing forms of multiple sclerosis (MS) to slow the worsening of symptoms common in people with MS and to decrease the number of flare-ups (relapses). TYSABRI increases the risk of progressive multifocal leukoencephalopathy (PML). When starting and continuing treatment with TYSABRI, it is important to discuss with your doctor whether the expected benefit of TYSABRI is enough to outweigh this risk.

Important Safety Information

TYSABRI increases your risk of getting a rare brain infection—called progressive multifocal leukoencephalopathy (PML)—that usually leads to death or severe disability.

Before receiving TYSABRI, it is important to tell your doctor:
TYSABRI can cause serious side effects. If you have any of the symptoms listed below, call your doctor right away:
The most common side effects of TYSABRI are:
These are not all of the possible side effects of TYSABRI. For more information, ask your doctor. To report side effects to FDA, please call 1-800-FDA-1088.

Please see Full Prescribing Information (PDF) including Boxed Warning and Patient Medication Guide (PDF).

This information is not intended to replace discussions with your healthcare provider.