About TYSABRI

What is TYSABRI?

• TYSABRI is a prescription medicine approved for adult patients with relapsing forms of MS to slow the worsening of physical disability that is common in patients with MS and decrease the number of flare-ups (relapses).
• Because TYSABRI increases the risk of progressive multifocal leukoencephalopathy (PML), a rare brain infection that usually causes death or severe disability, TYSABRI is generally recommended for patients that have not been helped enough by, or cannot tolerate, another treatment for MS.
• TYSABRI does not cure MS and has not been studied for longer than two years or in patients with chronic progressive MS.

Is TYSABRI Effective?

• TYSABRI has been proven to positively affect key components of MS:
  • Reduces flare-ups
  • Slows down the progression of physical disability

• TYSABRI may also:
  • Reduce the number of new brain lesions detectable on MRI*

*Changes in MRI often do not relate to how your MS is progressing.

What makes TYSABRI different?

1. The exact way that TYSABRI works is not fully understood but, TYSABRI is different and appears to work differently.
   • TYSABRI is an antibody, not an interferon (AVONEX^® (interferon beta-1a), Betaseron^® (interferon beta-1b), Extavia^® (interferon beta-1b), Rebif^® (interferon beta-1a)) or glatiramer acetate (Copaxone^®)^†
   • TYSABRI is thought to inhibit white blood cells from getting into the brain and attacking nerves
   • Keeping these cells from attacking nerves is believed to result in fewer brain lesions** that cause multiple sclerosis symptoms

   **Changes in MRI often do not relate to how your MS is progressing.

2. TYSABRI is taken differently than other multiple sclerosis medicines. With TYSABRI:
   • You can avoid the hassles of self-injection
   • You only have to think about taking your MS treatment once every 4 weeks

^†AVONEX is a registered trademark of Biogen Idec. All other trademarks are the property of their respective owners.

The Effectiveness of TYSABRI MS Therapy
TYSABRI may offer many people with relapsing forms of MS the strength to reach for their high hopes. TYSABRI has been proven to slow the worsening of physical disability and lower the frequency of flare-ups. TYSABRI may also reduce the number of new and newly active MRI lesions. However, changes in MRI often do not relate to how your MS is progressing.

Is TYSABRI MS Treatment Right For Me?
TYSABRI should only be used by certain people. It's important that you talk with your doctor about whether you might be a good candidate for TYSABRI.

What You Need To Know Before Taking TYSABRI
Treatment with TYSABRI has potential benefits and risks, including serious risks. Weighing these potential benefits and risks allows you to make an informed choice.

TYSABRI Side Effects
Treatment with TYSABRI may come with side effects, including serious side effects. Learn more about any potential side effects here.

How TYSABRI Works
TYSABRI is different. Learn more about the different way TYSABRI works.