The Effectiveness of TYSABRI MS Therapy

How much could TYSABRI help me?

Not all multiple sclerosis (MS) treatments have been proven to do the same things. TYSABRI has been proven to positively affect key components of MS. TYSABRI is approved to:

• Slow the worsening of physical disability
• Decrease the number of flare-ups

TYSABRI may also reduce the number of new brain lesions detectable on MRI.
However, changes in MRI often do not relate to how your MS is progressing.

On this page, you'll learn in more detail how TYSABRI:

• Reduces flare-ups
• Slows down the progression of physical disability
• May reduce new lesions and new lesion activity

Reduces flare-ups 

For many people with MS, reducing the number of flare-ups may help reduce permanent future disability.

At the end of a 2-year study, TYSABRI reduced how often flare-ups occurred by 67% compared with placebo. The average number of flare-ups a patient had each year was 0.22 for TYSABRI and 0.67 for placebo.

Of patients who took TYSABRI in the 2-year study, more than 6 out of 10 had no flare-ups at all.

• 67% of people taking TYSABRI had no flare-ups at the end of the 2-year study compared with 41% of people receiving placebo

Slows down the progression of physical disability 

In the same 2-year study, TYSABRI slowed the worsening of physical disability that is common in people with MS. TYSABRI reduced the chance a person's physical disability would worsen by 42% compared with placebo.

• 17% of people taking TYSABRI had their physical disability worsen compared with, 29% of people taking placebo

What does this mean to you?

Of people who took TYSABRI in the 2-year study, more than 8 out of 10 had no physical disability progression.

• 83% of people taking TYSABRI had no physical disability progression at the end of the 2-year study, compared with 71% of people taking placebo

To figure out if physical disability is progressing in studies like this one, doctors use a scale called the Expanded Disability Status Scale (EDSS). The EDSS is a way of measuring physical disability.

One goal of MS treatment is to reduce progression past a score of 4.0 on the EDSS, a point at which disability starts to affect multiple things you do.

Disability Progression (EDSS)

Fewer new or newly active MRI lesions* 

TYSABRI can also reduce the number of brain lesions you have. Brain lesions seen on an MRI show areas of badly damaged nerves.

At the end of a 2-year study, 97% of people taking TYSABRI had no new lesions that showed disease activity compared with 72% of people taking placebo.

Changes in MRI often do not relate to how your MS is progressing.

This means that 9 out of 10 people taking TYSABRI had no new lesions that show new disease activity.

Talk to your doctor about TYSABRI