The Effectiveness of TYSABRI MS Therapy

Getting Diagnosed with MS

How much could TYSABRI help me?

Not all multiple sclerosis (MS) treatments have been proven to do the same things. TYSABRI has been proven to positively affect key components of MS. TYSABRI is approved to:

• Slow the worsening of disability
• Decrease the number of flare-ups

TYSABRI may also reduce the number of brain lesions detectable on MRI.^*

TYSABRI has been shown to improve mental function and physical disability in some patients.

^*It is not known if MRI findings relate to how well your MS is progressing.

For many, Freedom from MS disease activity

TYSABRI may improve mental function

TYSABRI may improve physical function

Reduces flare-ups 

For many people with MS, reducing the number of flare-ups may help reduce permanent future disability.

At the end of a 2-year study, TYSABRI reduced how often flare-ups occurred by 67% compared with placebo. The average number of flare-ups a patient had each year was 0.22 for TYSABRI and 0.67 for placebo.

Based on the results of a 2-year study, people taking TYSABRI may be able to experience up to 4.5 years without a relapse compared with only 18 months for patients taking placebo.

Of patients who took TYSABRI in the 2-year study, more than 7 out of 10 had no flare-ups at all.

• 72% of people taking TYSABRI had no flare-ups at the end of the 2-year study compared with 44% of people receiving placebo

Slows down the progression of MS 

In the same 2-year study, TYSABRI slowed the worsening of disability that is common in people with MS. TYSABRI reduced the chance a person's disability would worsen by 42% compared with placebo.

• 17% of people taking TYSABRI had their disability worsen, while 29% of people taking placebo had their disability worsen

What does this mean to you?

Of people who took TYSABRI in the 2-year study, more than 8 out of 10 had no disability progression.

• 83% of people taking TYSABRI had no disability progression at the end of the 2-year study, compared with 71% of people taking placebo^†

To figure out if disability is progressing in studies like this one, doctors use a scale called the Expanded Disability Status Scale (EDSS). The EDSS is a way of measuring physical disability.

One goal of MS treatment is to reduce progression past a score of 4.0 on the EDSS, a point at which disability starts to affect multiple things you do.

^†Based on a review of a 2-year study, 220 patients out of 600 taking TYSABRI versus 22 patients out of 304 taking placebo were free of disease activity over 2 years.

Disability Progression (EDSS)

Fewer new or newly active MRI lesions* 

TYSABRI can also reduce the number of brain lesions you have. Brain lesions seen on an MRI show areas of badly damaged nerves.

In a 2-year study, 97% of people taking TYSABRI had no new lesions that showed disease activity compared with 72% of people taking placebo.^†.

This means that 9 out of 10 people taking TYSABRI had no new lesions that show new disease activity.

*It is not known if MRI findings relate to how well your MS is progressing.

^†Based on a review of a 2-year study, 220 patients out of 600 taking TYSABRI versus 22 patients out of 304 taking placebo were free of disease activity over 2 years.

For many, freedom from MS disease activity 

Over a 2-year period, 36.7% of people taking TYSABRI, compared to 7.2% taking placebo, had:

• NO flare-ups
• NO disease progression
• NO new or newly active MRI lesions*

This means more than 1 out of 3 people taking TYSABRI were considered to be free from disease activity, because they had no flare-ups, no disease progression, and no new or newly active MRI lesions.*

*It is not known if MRI findings relate to how well your MS is progressing.

Therefore, 5 times more people taking TYSABRI lived free from MS disease activity compared with people who received placebo.^†

^†Based on a review of a 2-year study, 220 patients out of 600 taking TYSABRI versus 22 patients out of 304 taking placebo were free of disease activity over 2 years.

TYSABRI may improve mental function 

MS may impact your mental, or "cognitive," function

Cognitive function refers to brain activity that affects things like:

• Memory
• Attention and concentration
• Information processing

People taking TYSABRI showed a 69% improvement in cognitive function compared to placebo (0.22 improvement for people taking TYSABRI compared with 0.13 improvement for people taking placebo) in a 2-year study.^*

^*As measured by the 3-second Paced Auditory Serial Addition Test, which measures mental abilities.

TYSABRI may improve physical disability 

In a 2-year study, patients who started with an EDSS score ≥2 taking TYSABRI were 69% more likely to show improvement in their disability than people taking placebo (30% of people taking TYSABRI improved compared with 19% of people taking placebo).^*

In the 2-year study, of those who benefited, TYSABRI improved the physical score by up to 1 point on the EDSS. Here are some examples of what that could mean:

Talk to your doctor about the proven power of TYSABRI.

^*Based on a review of a 2-year study, which assessed a total of 620 patients (417 taking TYSABRI compared with 203 taking placebo).